Friday, November 1, 2013

Dysfunctional chemokine receptor promotes candidiasis

Dysfunctional chemokine receptor promotes candidiasis


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PUBLIC RELEASE DATE:

1-Nov-2013



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Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation






Candida albicans is one of the leading causes of hospital-acquired infections in immune compromised patients. The risk of both developing candidiasis and the clinical outcome of infection is variable among patients, and the host-dependent factors that contribute to patient susceptibility to C. albicans infection are poorly understood. In this issue of the Journal of Clinical Investigation, Michail Lionakis and colleagues at the National Institute of Allergy and Infectious Diseases demonstrated that the chemokine receptor CX3CR1 is required for the interaction of C. albicans and macrophages in the kidney. Mice lacking this receptor were prone to C. albicans-induced kidney failure; however, these mice did not have increased fungal burden in other organs. Furthermore, the authors found that patients with a mutation in the gene encoding CX3CR1 were at higher risk of candidiasis. This study identifies an important role for the interaction of C. albicans and macrophages in disease progression and outcome.

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TITLE:
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival

AUTHOR CONTACT:
Michail Lionakis

NIAID NIH, Bethesda, MD, USA

Phone: 301-443-5089; Fax: 301-480-5787; E-mail: lionakism@mail.nih.gov

View this article at: http://www.jci.org/articles/view/71307?key=c09c9f7b1f8d1860c357



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Dysfunctional chemokine receptor promotes candidiasis


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

1-Nov-2013



[


| E-mail

]


Share Share

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation






Candida albicans is one of the leading causes of hospital-acquired infections in immune compromised patients. The risk of both developing candidiasis and the clinical outcome of infection is variable among patients, and the host-dependent factors that contribute to patient susceptibility to C. albicans infection are poorly understood. In this issue of the Journal of Clinical Investigation, Michail Lionakis and colleagues at the National Institute of Allergy and Infectious Diseases demonstrated that the chemokine receptor CX3CR1 is required for the interaction of C. albicans and macrophages in the kidney. Mice lacking this receptor were prone to C. albicans-induced kidney failure; however, these mice did not have increased fungal burden in other organs. Furthermore, the authors found that patients with a mutation in the gene encoding CX3CR1 were at higher risk of candidiasis. This study identifies an important role for the interaction of C. albicans and macrophages in disease progression and outcome.

###

TITLE:
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival

AUTHOR CONTACT:
Michail Lionakis

NIAID NIH, Bethesda, MD, USA

Phone: 301-443-5089; Fax: 301-480-5787; E-mail: lionakism@mail.nih.gov

View this article at: http://www.jci.org/articles/view/71307?key=c09c9f7b1f8d1860c357



[ Back to EurekAlert! ]

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]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-11/joci-dcr102513.php
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