You can pout and you can shout, but there's no avoiding it: You'll soon be forced to use a new profile page design ? better known as the Timeline ? on Facebook. It'll be alright though, because we're here to (virtually) hold your hand through this big life change.
Source: http://www.msnbc.msn.com/id/42218772/vp/46134170#46134170
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NEW ORLEANS ? The Louisiana Seafood Promotion and Marketing Board says it may use some of the $30 million it received from BP PLC after the 2010 Gulf of Mexico oil spill to buy naming rights for the New Orleans Arena, where the NBA's Hornets play.
Executive director Ewell Smith said Tuesday the promotional value would be part of a campaign to restore confidence in Gulf seafood. Many seafood grounds were closed during the spill.
Smith said the campaign could include setting up Louisiana seafood vendor booths at other NBA arenas around the country.
He said the board has spoken with the Hornets and is awaiting more information. The arena is state-owned. A deal, he said, could come within 90 days.
The naming rights proposal was first reported in The Courier of Houma.
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BANGKOK ? Fireworks set off during an official Chinese New Year celebration have sparked a blaze that burned homes, killed three people and injured others in central Thailand.
Suphanburi Governor Somsak Phureesrisak told TPBS TV by telephone the three were killed as at least 20 houses burned down late Tuesday.
Somjate Promsuntorn, head of the Disaster Prevention and Mitigation Office, said at least 20 people were injured. A local hospital, however, told Springnews.tv that it had treated 57 people.
The fireworks were part of an elaborate celebration led by former Prime Minister Banharn Silpa-archa. His political machine dominates prosperous rice-growing Suphanburi province.
He told TV Channel 9 the celebration would continue but without any more fireworks.
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LITTLE ROCK, Ar?? Strong winds, heavy rains and golf-ball sized hail lashed parts of Arkansas late on Sunday, as forecasters issued tornado warnings and cautioned that storms could mete out damage to several southeast states into Monday.
Don't miss these Travel stories
The bigger the city, the bigger the attitude ? or at least its perceived attitude.
The potential for severe storms stretched from the Gulf of Mexico in Mississippi to southern Indiana and Ohio, according to AccuWeather.com meteorologist Bill Deger.
"Some of the thunderstorms are even expected to spawn tornadoes, making for an especially dangerous situation given the veil of night," Deger said.
Heavy rainfall had already begun to fall in Little Rock, with ping-pong ball sized hail falling across the state and wind gusting up to 70 miles per hour.
Funnel clouds were spotted within 20 miles of Little Rock, according to a national weather service alert.
In Alabama, residents were bracing for storms that could hit after dark on Sunday or overnight with a strong cold front from the west combining with warm moist air flowing up from the Gulf of Mexico, said Mary Keiser, meteorologist with the National Weather Service in Birmingham, Alabama.
"The best dynamics for this are going to be across the northwest part of the state and lesser so as you move to the southeast part of the state," Keiser said of the forecast for severe weather to strike in Alabama.
The weather service said thunderstorms could bring wind gusts up to 80 mph, tornadoes or gulf ball-sized hail in Mississippi. Farther west, the weather service warned of a high fire danger in Texas with wind gusts of up to 50 mph.
Weather.com said the greatest tornado threat appeared to be in eastern Arkansas, western Tennessee, northern Louisiana and northern Mississippi.
A second stormfront expected to hit California late Sunday night will bring significant snowfall to the mountain regions, according to the National Weather Service, before rolling into the southern United States later in the week.
Parts of central and southern California were under a winter weather warning as a storm system was expected to sweep into the area late Sunday into Monday morning, with the weather service predicting 6 to 12 inches of snow.
The Sierras and the Rockies may accumulate as much as 3 feet of snow, the weather service said, and driving in mountain passes will be "very hazardous" due to low visibility, gusting winds and heavy snowfall.
In Reno, Nevada, meanwhile, snowfall provided welcome relief to firefighters who were monitoring remaining hotspots from a blaze that raged near the outskirts of the city beginning Thursday, destroying 30 houses and prompting thousands of people to flee their homes.
"As long as we keep on getting snow instead of rain, it looks like we'll be okay, at least for the next couple of days," said Mark Regan, spokesman for the Sierra Fire Protection District.
Rain had threatened the area with flash flooding on Friday night. Emergency responders had the blaze 100 percent contained as of Saturday, and all residents have been allowed to return to their homes, Regan said.
In the upper Midwest, freezing drizzle was expected to make roads and sidewalks slippery from southeastern Minnesota into Wisconsin, changing to snow later Sunday, the weather service said. Up to 4 inches of snow was expected farther north in southeast North Dakota and west central Minnesota.
In the northeast United States, a fast-moving storm from central Pennsylvania eastward dropped up to a foot of snow in parts of Rhode Island and Massachusetts on Saturday.
Copyright 2012 Thomson Reuters. Click for restrictions.
Source: http://www.msnbc.msn.com/id/40493174/ns/travel-news/
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Russia has remained a staunch supporter of Syria's President Assad, blocking UN efforts to impose an international arms embargo.?
Russia has closed a contract to sell half-a-billion dollars worth of warplanes to Syria, just the latest sign that Moscow intends to?carry on business-as-usual?with the embattled regime of Syrian President Bashar al-Assad.
Skip to next paragraphAccording to the Moscow business daily Kommersant, the $550 million contract to purchase 36 Yak-130 Mitten combat trainers was signed in December, even as the 11-month-old uprising against four decades of rule by the Assad family was gathering steam and turning very bloody. According to United Nations estimates, more than 5,400 people have died since March, when the uprising began.?
Russian foreign minister Sergei Lavrov last week?dismissed any questions about Russian arms sales?to Syria?by saying "we don't consider it necessary to explain ourselves or justify ourselves, because we are not violating any international agreements or any [UN] Security Council resolutions."
The European Union approved an arms embargo on Syria last year. The UN Security Council has sought to do the same, but has been blocked by Russia, which has veto power.?
Experts say Russia has felt badly burned by Western-sponsored sanctions against selected Middle East regimes, which have cost Moscow some of its most lucrative customers, even as the US continues to negotiate huge arms sales to its own regional clients -- including recent deals worth?$60 billion to Saudi Arabia and $3.5 billion to the United Arab Emirates.
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There's good news and less-good news about AMD's new A8-3870K Accelerated Processing Unit (or APU). The good news is that it surpasses its predecessor, the A8-3850, in every way (if only slightly),
and provides overclocking features and performance potential beyond what you may think you can expect from a chip with a $135 (list) price?whether from AMD or Intel. But for all the strides AMD has made since it released the previous APU this past summer, the A8-3870K still can't replace a solid CPU?discrete video card combo for even quasi-serious gamers. But it shows that AMD is taking its Fusion product seriously, and thus hints at more good things to come.
Like the A8-3850, the A8-3870K is based on a 32nm production process and contains four CPU cores and a DirectX 11 (DX11)?supporting Radeon HD 6550D GPU with 400 GPU cores (in roughly the middle budget range of AMD's video products, judging by the previous generation's naming scheme). There's 128KB of L1 cache and 1MB of L2 cache available per core, and the APU supports dual-channel DDR3 memory at speeds of up to 1,866MHz. The A8-3870K of course also requires a motherboard that uses the (relatively) new FM1 socket, based on either AMD's A75 (with enhanced USB 3.0 and SATA III support) or A55 (USB 2.0 and SATA II) chipsets.
One important reminder about the graphics system on the APU: If you have a discrete video card installed, the APU will by default function as the boot-up video adapter, meaning any displays connected to a video card won't work until Windows loads the proper video drivers. This can be annoying if you only have one display, but you can toggle this "feature" in the motherboard's BIOS or UEFI settings. Second, the APU lets you access AMD's new Dual Graphics technology to "combine" the power of a discrete GPU with the integrated graphics; but this only works if both your hardware (the video card must be relatively low-end, and if you're only using one DIMM of memory, the whole thing might not work) and software (you'll need the AMD Vision Engine Control Center running) is correctly configured. Make sure your PC meets all the requirements before trying it out.
The biggest difference between the A8-3850 and the A8-3870K is in terms of the clocks. The CPU core on the newer chip has been bumped up from 2.9GHz to 3GHz, though the GPU clock remains unchanged at 600MHz?but both are now unlocked. This means you may overclock them to your heart's (and your PC's thermal) content, independently of each other, to get as much new performance as you can muster. It's also one of the first genuinely compelling reasons we've seen for enthusiasts (or just wannabes) to consider an APU that, by the broader standards of AMD's product line, is not an exceptional performer.
As we said when we reviewed the A8-3850 last year, Intel doesn't have any products that directly compare with AMD's new APUs in terms of overall capabilities. But if you care about raw processing more than graphics, an Intel platform based on chips like the lower-end Core i3-2100 or the considerably more powerful Core i5-2500K will serve you better. At its stock clock speeds, the A8-3870K represents only a tiny increase over the A8-3850; its multicore CineBench R11.5 score rose from 3.46 to 3.55, it took only six seconds less (5 minutes 12 seconds versus 5 minutes 18 seconds) to apply 12 filters in Adobe Photoshop CS5, cryptography throughput in TrueCrypt 7.0 raised from 106MBps to 109MBps, and its score in our full-system Futuremark PCMark 7 benchmark was functionally unchanged.
Video tests showed similarly small increases, with scores rising from 1,024 to 1,026 in 3DMark 11, frame rates increasing from 6.3 frames per second (fps) to 6.4fps in Lost Planet 2, and frame rates not improving at all in the Heaven Benchmark 2.5 (it remained at 5.5fps both times). These were all at basic resolutions, by the way?the Performance (1,280 by 720) preset for 3DMark 11, and 1,280 by 1,024 for the other two?though we maxed up all the details. By reducing the titles' resolutions or turning down the visual effects, you'll be able to get something much closer to playable frame rates, but you'll be making quite a few sacrifices.
This is where the overclocking comes in, right? Theoretically. We're happy to report that overclocking (when the APU was installed in the Gigabyte GA-A75-UD4H motherboard) was a breeze, and being able to separately focus on the CPU and GPU was an enormous frustration reducer. We had very little trouble nudging the GPU clock up from 600MHz to 900MHz and the CPU clock from 3GHz to 3.5GHz, using just a basic air cooler?and AMD tells us that, with more aggressive cooling and fine tuning of voltages, a combo rate of 960MHz/3.8GHz is possible. The A8-3870K offers you a lot of leeway.
But is it worth it? That depends on your point of view. The 3DMark 11 score rose from 1,026 to 1,244, CineBench from 0.90 to 1.04, the Heaven Benchmark from 5.5fps to 6.4fps, Lost Planet 2 from 6.4fps to 7.5fps, PCMark 11 from 2,509 to 2,691, Photoshop times down from 5:12 to 4:36, and TrueCrypt throughput up from 109MBps to 119MBps. (Predictably, load power rose as well, from 134.6 watts to 142.3 watts.) These aren't poor jumps by any stretch of the imagination. But except for those who might be really excited to overclock with such an inexpensive chip, we're not sure they're dazzling enough to set many hearts racing.
Still, the AMD A8-3870K is a fascinating part that shows how serious AMD continues to take the mainstream processor race. Our conclusion with this APU remains the same as with the A8-3850: Though you'll want a standalone video card for any real gaming purposes, AMD's blending of processing and video performance delivers a balance you just can't get from Intel right now. This may change when Intel ships its Ivy Bridge CPUs, which will support advanced DX11 graphics rather than Sandy Bridge's DX10, in a few months. But for now, AMD's Fusion approach is generating the most comforting heat in the midrange market.
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Getty Images49ers quarterback Alex Smith runs in for a touchdown during his team's victory over the Saints in the divisional playoffs last Saturday.
updated 6:06 p.m. ET Jan. 20, 2012
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?We want Carr. We want Carr!?
It was the lowest moment of Alex Smith?s seven-year career in San Francisco, Oct. 12, 2010. The winless 49ers hosted the Eagles on Sunday Night Football, and the crowd was looking for blood.
After his fourth-quarter fumble, thunderous boos poured down on Smith. He was hearing it all game from the crowd, but this matched anything I?ve ever heard ? even in Philadelphia. The unmistakable chant that came with the booing was even more depressing.
?We want Carr. We want Carr!?
The home crowd wanted Smith benched in favor of backup quarterback David Carr. The fan base collectively waved the white flag. They were tired of their No. 1 overall pick bust and wanted to try another. It was only Week 5 of a rapidly devolving season.
Coach Mike Singletary tried to remove Smith from the game, but the quarterback barked back. He talked his way into staying in the contest. He wound up throwing for more than 300 yards with three touchdowns in a comeback attempt that fell just short, like so many other 49er games during Smith?s tenure.
The fans got their wish two weeks later when Carr replaced an injured Smith during a loss to the Panthers. Troy Smith wound up starting six games for the 2010 49ers. Alex Smith?s beleaguered run in San Francisco was all but over. If nothing else, that gave the fans something to smile about.
Between rare and extinct
David Carr tells us a lot about Alex Smith. Just like Smith, Carr was a No. 1 overall draft pick viewed as a franchise savior. Like Smith, Carr fell flat on his face.
Carr didn?t face the same injury struggles as Smith. Carr didn?t have two head coaches question his toughness. But after five years in Houston, Carr was beat up mentally and physically. When Carr hit free agency, he wanted to take a break.? He wanted out.
"I need to take a deep breath and be around a good environment and just start enjoying the game again,'' Carr said in 2007. ?I wanted to be on a team that was fun and exciting and whether I had a chance to play right away, it didn't matter to me.''
Smith had his chance to take a deep breath last offseason. His family wanted him to leave San Francisco, toasting to new beginnings after this season. Smith didn?t want to go anywhere.
That desire to finish what he started won over new 49ers coach Jim Harbaugh.
"I wanted to get to know him. I had never met him," Harbaugh said last week of his first meeting with Smith in January 2011. "I was just kind of looking in through the keyhole. But I guess the things that I wanted to know, if you boiled it down to one thing, was, did he want to start? Did he want be in the fire? Or did he want to wear the ball cap backward and backup somewhere??
Harbaugh was asking if Alex Smith wanted to be David Carr. (Or Vince Young. Or Matt Leinart. Or JaMarcus Russell.)"I really felt that he had the competitive drive, the (desire) to prove himself, him wanting to do it here. That's the thing that probably intrigued me the most. That character of wanting to come back and do it here in San Francisco, which is pretty rare ? probably somewhere between rare and extinct. That's not just for football players. That's about anybody. ... And I thought we could really work with that character. To me that was special."
Smith?s seven fourth-quarter comeback victories this season are special. His league-leading interception percentage says a lot. But the most impressive part of Smith?s season is that he?s there at all. He survived.
The things Alex carries
Alex Smith carries his six seasons through the professional football meat grinder everywhere he goes. He carries the old playbooks; the losses; the chants; the manipulative coaches; the shoulder surgeries.
Smith has gone through this 14-3 season hesitant to look back. It?s as if he doesn?t want to jinx what?s happening.
Seven offensive coordinators
Smith?s first offensive coordinator was Mike McCarthy, who pushed the team to draft Smith over Aaron Rodgers with the No. 1 pick in 2005.
One touchdown, 11 interceptions by Smith later, McCarthy scored the Packers' head coaching job before his coaching stock sunk any further.
Norv Turner came next and guided Smith to a promising second season. Smith appeared to have turned a corner. It?s a reminder what good teaching can mean for a young quarterback.? Smith wouldn?t learn that lesson again until 2011.? Turner left after ?06 for the Chargers head coaching job.Jim Hostler, Mike Martz, Jimmy Raye, and Mike Johnson followed Turner to disappointing results. Each man had a new idea of how an NFL offense should look and how Smith fit into their system. Some liked Smith more than others. Every spring meant a new playbook.
Smith?s seventh coordinator was the charm. Jim Harbaugh knows the quarterback position as well as any head coach, but he also brought in a terrific staff to help him. It?s one of the most underrated skills a head coach can have. Can he choose the right men to assist him?
Offensive coordinator Greg Roman and quarterbacks coach Geep Chryst have both done a fabulous job with Smith. It was Chryst who took over the play-calling late in the divisional round win over the Saints. Along with Harbaugh, the three men collaborate on one of the smartest offensive attacks in the league.
They create big-play opportunities without taking much risk. They accentuate what Smith does well and limit his weaknesses being exposed. They put Smith in position to succeed. That?s coaching.
2 misguided head coaches
Alex Smith?s rookie season was Mike Nolan?s rookie season as a head coach. Both men looked comfortable in their new role.
Nolan ran the 49ers through fear. He often seemed unnecessarily paranoid and played misguided mental games. When Smith?s shoulder was hurt in 2007, Nolan implied publicly that Smith wasn?t fighting through the injury. Nolan came out told the 49ers team behind closed doors that Smith was using his shoulder injury as an excuse for poor play. Smith fought back by speaking out.
?I felt it was trying to undermine me with my teammates,? Smith said back then.
Smith had shoulder surgery after the season.
The next 49ers head coach was a defensive-minded motivational speaker: Mike Singletary. Singletary said multiple times he didn?t think quarterback was the most important position on the field. He once called Smith ?meek.? After Singletary was fired, he was asked what he learned from the experience.
"You gotta have a quarterback," Singletary said.
These were the men in charge. They never believed in Smith.
Harbaugh saw something different in that first meeting with Smith. Most importantly, he saw a quietly improved player on film. Harbaugh?s effusive and immediate praise of Smith almost seemed comical. (He once said Smith had ?armadillo skin .?)
Smith, a free agent, publicly expressed doubt he?d return to San Francisco before Harbaugh started recruiting Smith with regular meetings. No one in San Francisco knew what to make of it. Why would the new hot shot coach stick out his neck for Smith?
?I?ve been studying Alex Smith and watching him and I believe that Alex Smith can be a winning quarterback in the National Football League,? Harbaugh said. ?Very accurate passer. Very athletic. And a guy that has played and been durable.?
This was January 2011. Harbaugh embraced the quarterback no one wanted. The message hasn?t changed since. The love affair has only grown.
The teammates
Smith was benched for the following quarterbacks during his 49ers career: Tim Rattay, Ken Dorsey, Trent Dilfer, Shaun Hill, J.T. O?Sullivan, and Troy Smith.
Guys like Carr and Cody Pickett replaced Smith when he was hurt. Only Hill went on to a modicum of success after leaving San Francisco.
The following wide receivers have started games during Smith?s tenure in San Francisco: ?Brandon Lloyd, Arnaz Battle, Johnnie Morton, Kevin McAddley, Antonio Bryant, Bryan Gilmore, Darrell Jackson, Ashley Lelie, Isaac Bruce, Bryant Johnson, Jason Hill, Josh Morgan, Michael Crabtree, Braylon Edwards, Ted Ginn, Kyle Williams, and Brett Swain.
Change was the only constant in San Francisco?s passing attack. Personnel objectives changed annually with the rotating offensive systems. Players past their prime were brought in like Morton, Jackson, and Bruce. Failed draft picks from other teams were given a second chance like Lelie, Johnson, Edwards, and Ginn. Very little stuck.
Even today, San Francisco?s wide receivers struggle to beat man coverage. It?s a concern this week going against a Giants defense that can get pressure with their front four and played great man coverage last week in Green Bay.
Harbaugh knows all this. He built an offense around the run game, his tight ends, and carefully orchestrated ?shot plays? the wideouts wouldn?t have to win consistently on the outside. He relied on Smith?s accuracy and decision making.
When Harbaugh has asked Smith and his receivers to carry the offense ? against the Giants and Saints ? they have found a way.
Bad habits
Smith deserves his share of blame for struggling until Harbaugh came along. He doesn?t have the big arm you?d expect of a top pick. He?s smart but has struggled to translate those smarts into instinct. He was deliberate making decisions.
Going back through five years of my game notes, the same word came up repeatedly describing Smith: tentative. He took the safe play. He didn?t have enough confidence in himself, his receivers, or perhaps his offense to make the difficult throw.
That slowly started to change this year. The 49ers are not an aggressive passing team, but Smith has played his best with the game on the line.
Back-to-back fourth-quarter comeback wins in Cincinnati and Philadelphia kick-started things. Smith threw a fourth-and-goal game-winner to Delanie Walker in Detroit. An insane 41-yard toss to Michael Crabtree set up the game-winning field goal in Seattle.
In most of those games, the 49ers still coached around Smith. Their wins were more about the defense, running game and short, safe passes. Last Saturday against the Saints, the 49ers coaching staff gave the keys to Smith."The winning touchdown to Vernon Davis ... and I'm taking nothing away from Vernon Davis's catch ... the throw made that play, not the catch," NFL Films guru Greg Cosell said on KNBR this week. ?He threw that ball before Davis even got past the underneath linebacker.?
The 49ers could have played for the tie, but they went for the win because of the confidence they had in Smith. It was the type of instinctive, anticipatory, gutsy throw we haven?t seen from Smith. Smith is starting to mix in aggression with his smarts. That could be a championship combination.
The other side
Alex Smith is Mark Sanchez if Sanchez went through another three years like the one he just had.
Smith took all the abuse we could hurl at him and emerged on the other side. He will never be Joe Montana, but that?s not the point. He?s here. He is one game away from playing in the Super Bowl. After what Smith has been through, he deserves to enjoy this moment.
Perhaps Smith will take a deep breath during the national anthem on Sunday and allow himself a peak at the opposing sideline. Giants backup quarterback David Carr will be standing there, representing the road more traveled.
When the anthem ends, Carr will reach to put on his backward hat. Smith will grab his helmet.
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More newsGetty ImagesCSN: We revere Noll, Shula, Lombardi, Walsh and Brown, but Bill Belichick could wind up the greatest coach ever ? and it's a lot harder now.
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'There were a lot of moments in the video that ... should have ended a lot worse than they did,' band says.
By James Montgomery
FUN.
Photo: MTV News
Fun.'s "We Are Young" video is the kind of thing that practically begs for repeat viewings ... a stirring, swirling collection of slow-motion imagery (bodies flailing, glass shattering and the like) that pops from the screen, it's far and away the first breakout clip of 2012. Thankfully for the guys in the band, it was also the kind of video where repeat takes weren't allowed. Mostly because, well, someone could've gotten hurt.
"It was terrifying. There were a lot of moments in the video that I think should have ended a lot worse than they did," guitarist Jack Antonoff laughed. "I watch the video and I think, 'Oh God, we really threw ourselves in some real danger there,' because it's a bunch of stunt people and then us. And it's not necessarily healthy to have cake rocketed at your face from an air cannon, but we did it. And we're in serious tuxedos that are very constricting, so if you want to get away from something quick, you want to be in a sweat suit or something."
"There was a palm tree that flips by [multi-instrumentalist] Andrew [Dost's] head, and I was watching and I had no idea how far away that palm tree was from his head," frontman Andrew Ruess added. "I was so scared, for real."
Of course, all that danger was just part of what made the "Young" video such a challenge for Fun. The other part? Well, that would be living up to the rather ginormous goals they had set for themselves ... namely, to single-handedly resurrect the music video medium from its current doldrums.
"We were really adamant about getting back to the heyday of music videos, you know, the mid-'90s, when we were growing up," Antonoff said. "Videos like [the Smashing Pumpkins'] 'Tonight, Tonight' and Spike Jonze's slow-motion 'Wax' video ['California'] ... just these videos where it's not some giant narrative, and it's not a mini-movie, it's a cool music video. It's kind of abstract, but to us, it makes sense."
And really, that grandiose spirit of just going for it is also what fuels the band's wide-screen, everything-but-the-kitchen-sink album Some Nights (due February 21). It is very much the sound of a band breaking barriers, pushing boundaries and gunning for the big time ... and, yes, Fun. will happily admit to all of those things. After all, they've been working toward this moment for nearly a decade now, and they're going to take full advantage. Even if it kills them.
"It's been a long time coming," Ruess said. "And we want it to take over the world."
"It all seems like, if you're pop, you go big, if you're indie, you go small and you're self-deprecating. We just think we can do both, you know?" Antonoff said. "If we have a song that sounds like it's meant to be played for 10,000 people, like 'We Are Young,' then we'd like to try to do that, and we'd like to try and make a video that reflects that."
Related ArtistsSource: http://www.mtv.com/news/articles/1677668/fun-we-are-young-video.jhtml
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ScienceDaily (Jan. 18, 2012) ? A novel technique has been developed and demonstrated at Penn State to map the proteins that read and regulate chromosomes -- the string-like structures inside cells that carry genes. The specific order in which these proteins attach DNA-containing nucleosomes along the chromosome determines whether a brain cell, a liver cell, or a cancer cell is formed. Until now, it has been exceedingly difficult to determine exactly where such proteins bind to the chromosome, and therefore how they work.
The new technique precisely pinpoints their location, and has the potential to take high-resolution snapshots of proteins as they regulate or miss-regulate an entire genome. The research was published January 18 as an Advance Online Publication in the journal Nature. Related research by the Penn State scientists recently was published in the journal Cell.
The research process, lead by Willaman Professor of Molecular Biology B. Franklin Pugh with graduate student Ho Sung Rhee, began by their using a molecular tool called an exonuclease to remove DNA that is not bound by one of the gene-regulating proteins. They then determined the nucleotide sequence for each of the remaining protein-bound DNA bundles -- the sequence of the four major component bases of DNA, labeled A, T, C, and G.
"The advantage over other techniques of this technique, called ChIP-exo, is its ability to narrow down any binding location across millions and billions of nucleotide genomes to a certainty of about one nucleotide," Pugh said. "This improvement is roughly analogous to going from a low-resolution 240p television to a high-definition 1080p home-theater system. It provides an unprecedented view into how genes are regulated."
The ChIP-exo technique also removes a substantial amount of noise in the detection system that plagues other methods. The lower-noise technique reveals two to five times more binding locations, providing a much more complete picture of which genes are regulated by a particular protein, as well as a broader understanding of their structural organization across genomes. Having a more complete picture allows scientists to understand in more detail how gene pathways work in normal human development, or fail to work in disease.
This research was funded by the National Institute of General Medical Sciences of the U. S. National Institutes of Health.
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WASHINGTON?? It's all fun and margaritas when you first book a cruise. But that "ticket" is actually a contract that can run more than a dozen pages, and gives away more rights to the cruise ship company than you may realize.
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"People will buy the ticket without knowing this, and they won't even look at it before they step on the cruise ship," said Joseph Goldberg, a Harrisburg, Pa.-based consumer attorney who reviewed the ticket contract posted on the Carnival Cruise Lines website for Reuters.
Carnival dominates about half of the cruise market, and its contract, which runs almost 8,000 words and mentions "liability" 20 times, could be considered typical for the industry.
"It's not until something does happen that you find out how stuck you are," Goldberg said.
Something did happen, of course. The Costa Concordia, operated by a company owned by Miami-based Carnival, ran aground in Italian waters on Friday, leaving at least 11 passengers dead and some 24 more missing. That was an extreme and unusual event, likely to have lawyers fighting for years over the various and sometimes contradictory laws, agreements and contracts that may come into play, according to Lewis "Mike" Eidson, a Miami trial lawyer who specializes in representing cruise passengers.
He said he expects to represent Costa Concordia passengers and crew members, and that he will argue that the usual contractual limitations shouldn't apply, because the particulars of this case were so extreme.
But anyone thinking of a nice mid-winter cruise should consider those limitations anyway. If you know what you're signing away, you may be able to protect yourself in the event of lesser tragedies, like lost luggage or a minor injury.
Here are seven rights you sign away when you buy a cruise ship ticket.
Furthermore, that contract gives Carnival the right to use pictures and videos of you any way they want. You may not want your office buddies seeing pictures of you in a bathing suit, but that image could make its way into a commercial, without Carnival paying you or getting any additional release signed by you.
If you're bringing expensive jewelry or other items on board, make a written list of the value, pay the 5 percent and make sure the crew gets a copy of that list, says Goldberg.
Furthermore, there are lawsuit deadlines in cruise contracts that many attorneys and passengers aren't even aware of, said Eidson. The contract requires injured parties to notify Carnival within six months and file suit within a year. "The biggest claim in the world could be defeated if you don't file your claim within the year," he said.
Copyright 2012 Thomson Reuters. Click for restrictions.
Source: http://www.msnbc.msn.com/id/46030557/ns/travel-cruise_travel/
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NEW YORK ? Eight years after he died of prostate cancer, Johnny Ramone's autobiography is finally being published.
"Commando: The Autobiography of Johnny Ramone" is set for release April 2 by Abrams Image. In an interview Tuesday, his widow, Linda, described the book as "kind of his last word that he knew would be out."
"It is a really powerful book because his whole life has gone before him and he knows it's going to come to an end, and he really needs to tell everybody what he's feeling inside, so that's what makes it so amazing," she added later. "That is the biggest, most powerful thing, writing a book when you know you're dying."
Johnny Ramone, whose real name was John Cummings, was one of the founding members of the legendary New York City-based punk band the Ramones, members of the Rock and Roll Hall of Fame. Considered one of the most influential guitarists in rock, he died in 2004 at age 55 after battling cancer for five years.
Linda Ramone said he started writing the book when he first became ill: "Johnny's legacy to him was so important, even while he was sick. ... It was like he knew he was dying, and he wanted to do something."
The 176-page book is filled with pictures selected by his wife. It includes Ramone's musings from his childhood to his struggle with cancer. It also features other personal stories, including the attack on him that left him hospitalized, his altercation with Malcolm McLaren and his romance with Linda, who once dated Joey Ramone, the Ramones' frontman, leading to a yearslong rift between the two musicians.
"It's whatever people make out of it. I guess it was some sort of love triangle ? Joey, Johnny and me. It happened, and of course he talks about it and he talks about how he feels about it," Linda said. "The three of us all probably have a different story, but this is Johnny's story."
Band mate Tommy Ramone, the only surviving member of the original band, wrote the foreword. In a statement, he said: "Johnny Ramone's autobiography is a no holds barred, straight-forward book written in a no-nonsense style that is Johnny personified. His story is written in his own actual words, so the reader gets an insight into what made him the unique, charismatic and exciting individual that he was. It also gives a great view of The Ramones from Johnny's perspective."
The epilogue was written by close friend Lisa Marie Presley.
Linda Ramone said the book was originally planned to have interviews with Ramone's friends, but she decided to only include her husband's words.
"It didn't make Johnny Ramone's book more powerful by having other people in the book talking about him," she said. "This is nobody else's story. This is Johnny Ramone's story, talking about Johnny Ramone."
She said several factors were responsible for the delay in the book's release, including lawsuits involving the band after Ramone died and other projects she was undertaking for his fans.
"Between all those years of doing different things for his legacy, I always had the book. But there was never the right time for the book," she said.
Linda said her husband never stopped working on the book, even during chemotherapy treatments.
"He wasn't feeling well all the time, but that never stopped Johnny," she said. "Johnny was indestructible."
She hopes to publish another book of photos of Ramone, and hopes the book will lead to a Ramones biopic.
"This is the first book I can honestly see that really has enough in it to make it such an interesting story, because this is Johnny talking about Johnny," she said. "No Ramone movie could be as cool as Johnny's story."
___
Online:
http://www.johnnyramone.com
___
Nekesa Mumbi Moody is the AP's music editor. Follow her at http://www.twitter.com/nekesamumbi
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WASHINGTON (Reuters) ? President Barack Obama's jobs council is calling for a corporate tax overhaul, expanded domestic drilling and new regulatory reforms, a set of proposals unlikely to provide a quick fix for high unemployment or gain much traction in an election year.
A panel of business leaders advising Obama -- whose re-election chances could hinge on whether he can boost the fragile U.S. economy - will offer its latest job-creation prescriptions at a meeting with him on Tuesday. A draft of its report was obtained by Reuters.
Obama's Council on Jobs and Competitiveness has generated dozens of ideas since it was created amid political fanfare last February, but implementation of some of its key recommendations has lagged and the overall benefits remain uncertain.
"There's not one silver bullet on jobs," General Electric Chief Executive Jeffrey Immelt, who chairs the non-partisan panel, acknowledged in an interview before the report's formal release at the White House.
Immelt insisted that a number of the panel's earlier proposals, such as streamlining infrastructure building permits, were bearing fruit and the new ones deserved bipartisan support.
That could be a tall order in a divided Congress where the Democratic president's jobs agenda has largely stalled in the face of Republican resistance and election-year gridlock.
LOFTY THEMES
While the council used two earlier reports to present specific, although mostly modest, jobs proposals, the latest - with the lofty title "Roadmap to Renewal" - lays out a broader strategy to promote manufacturing, education and innovation.
"Investing in our future, building on our strengths, and playing to win - these are mantras we must adopt, along with the specific policies and initiatives that back them up, if we are going to renew our competitiveness," the report states.
This will be the focus of Obama's meeting with the CEOs, the latest in a series of White House events aimed at showing voters he is serious about tackling unemployment.
The November 6 election is widely seen as a referendum on his economic leadership, and his record is under attack from Republican presidential contenders like front-runner Mitt Romney.
Among the steps the council sees as urgently needed is long-delayed reform of the corporate tax system, which it says is outdated and "hurts both business competitiveness and American workers." "The council urges Congress and the administration to begin work on tax reform immediately," the report says.
The panel calls for lowering corporate tax rates to "internationally competitive levels" while broadening the corporate tax base by eliminating deductions and loopholes.
But the report notes disagreement among council members over whether to shift to a "territorial" system that exempts most or all foreign income from corporate taxes when it is repatriated.
The administration said last summer it was developing a broad corporate tax reform plan, an idea Republicans have also pushed for years, but one never materialized.
The mammoth U.S. tax code has not been thoroughly overhauled in 25 years, and most analysts see little chance in an election year. But they expect that growing budget deficits and public dissatisfaction may open the door to reform efforts in 2013.
'ALL-IN' ENERGY STRATEGY
In a proposal likely to be opposed by environmentalists, the report calls for an "all in" strategy on energy that would seek to further exploit domestic fossil-fuel supplies to reduce reliance on foreign imports. But it also urges development of cleaner energy sources and promotion of energy efficiency.
"The Jobs Council recommends expanding and expediting the domestic production of fossil fuels - including allowing more access to oil, gas, and coal opportunities on federal lands - while ensuring safe and responsible development of those sites," the report said.
In addition, the report called for a series of reforms to streamline government rules and reduce the regulatory burden on businesses, which it said would enhance U.S. competitiveness.
Even though there is some common ground between Obama's Democrats and opposition Republicans, little movement is expected on these issues between now and Election Day.
Obama's strategy has been to cast Republicans as obstructing his economic recovery efforts, especially after they blocked much of his $447 billion jobs plan in September. Republicans charge that Obama has pursued failed spending policies.
The U.S. jobless rate dropped to a near three-year low of 8.5 percent in December, but employment remains about 6.1 million jobs below its pre-recession level.
(Reporting By Matt Spetalnick; Editing by Peter Cooney)
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PARIS ? Two giant pandas have arrived from China aboard a special plane and are heading to their new home amid the chateaux of central France.
Male Yuan Zi and female Huan Huan are France's first pandas since the death of one more than a decade ago.
The endangered animals get only the best: Their "Panda Express" plane, specially configured for their enclosures, was greeted with applause at the Paris airport.
On loan from China, Yuan Zi ("chubby" in Chinese) and Huan Huan ("happy") will live at the Zoo Parc de Beauval, in the Loire valley, for 10 years.
China has long used "panda diplomacy" to make friends and influence people in other countries. Last month, two pandas from China debuted at Scotland's Edinburgh Zoo.
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MIAMI ? Gene Hackman's publicist says the veteran Oscar-winning actor was briefly hospitalized after a truck bumped him from behind while he was riding a bicycle in the Florida Keys.
Susan Madore says the 81-year-old Hackman was airlifted to a Miami hospital Friday afternoon.
She characterized his injuries as minor bumps and bruises. She says he was released from the hospital several hours later after routine tests.
The Florida Highway Patrol reports that Hackman was riding on an Islamorada street around 3 p.m. when the pickup hit the back of his bicycle, throwing him onto the grassy shoulder. No charges were immediately reported.
Hackman won an Academy Award for "The French Connection" in 1971 and another for "Unforgiven" in 1992. He received Oscar nominations for three other films.
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There's a waiting list for a $67,000 world trip offered by TCS and Starquest Expeditions to four seasons hotels around the world.
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Twitter: I've only just noticed that an iPad is exactly the size and shape as a mouse mat. What can we infer from this? Source: http://twitter.com/SelfMadeHero/statuses/156771371387584512
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Sharp's putting out a plethora of new devices at CES, and among them is an addition to its existing 3D DLP projectors called the XV-Z30000. It's a 1600-lumen 3D projector that throws a 1080p image on whichever wall you point it at, and keeps the quality up thanks to a 50,000:1 contrast ratio. Connectivity comes courtesy of dual HDMI inputs and its got home automation control compatibility from all the big players along with LAN control as well. The XV-Z30000 comes with two sets of 3D glasses, and will be available for $5,000 in March 2012.Sharp's new XV-Z30000 HD DLP projector puts 3D video on the wall of your choosing originally appeared on Engadget on Mon, 09 Jan 2012 13:00:00 EDT. Please see our terms for use of feeds.
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Belkin reveals Advance N900 DB router, keeps your MW3 marathon top priority with IntelliStream originally appeared on Engadget on Sun, 08 Jan 2012 12:00:00 EDT. Please see our terms for use of feeds.
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